Photoelectron spectra of 2-thiouracil, 4-thiouracil, and 2,4-dithiouracil

Photoelectron spectroscopic study of the negative ions of 4-thiouracil and 2,4-dithiouracil.

We report the photoelectron spectra of the negative ions of 4-thiouracil (4-TU)(-) and 2,4-dithiouracil (2,4-DTU)(-). Both of these spectra are indicative of valence anions, and they are each dominated by a single broad band with vertical detachment energies of 1.05 and 1.4 eV, respectively. Complementary calculations by Dolgounitcheva, Zakrzewski, and Ortiz (see companion paper) are in accord ...

Thiouracil in Thyrotoxicosis

Enzymatic synthesis of thiouracil riboside and thiouracil desoxyriboside.

In a survey of various substrates for pyrimidine nucleoside synthesis, it was noted that inorganic orthophosphate was released when 2-thiouracil and desoxyribose-l-phosphate were incubated together with thymidine phosphorylase (1). This finding, taken as a fairly certain indication of nucleoside synthesis, has now been fully substantiated by isolation and characterization of crystalline thioura...

Copper (I) complexes of 2-thiouracil

Copper complexes obtained from the reactions between 2-thiouracil and cupric hydroxide in different solvents have been investigated. Mononuclear or polynuclear complexes of Cu(I) have been obtained depending on the reaction conditions. Hydroxo complexes of copper(I) have been obtained at pH around 3.5. 2-Thiouracil acts as monoor bidentate ligand in complexes. [Cu(H2TU)2 OH], [Cu5(H2TU)6 (OH)5]...

2-Thiouracil intersystem crossing photodynamics studied by wavelength-dependent photoelectron and transient absorption spectroscopies.

Single-atom substitution within a natural nucleobase-such as replacing oxygen by sulfur in uracil-can result in drastic changes in the relaxation dynamics after UV excitation. While the photodynamics of natural nucleobases like uracil are dominated by pathways along singlet excited states, the photodynamics of thiobases like 2-thiouracil populate the triplet manifold with near unity quantum yie...